Human Reproduction Archives
Human Reproduction Archives
Research Article Assisted Reproduction

Desogestrel for preventing a premature luteinizing hormone (LH) surge in a cycle for oocyte cryopreservation

Camila Karsburg Bessow, Rafaela Colle Donato, João Sabino Lahorgue da Cunha Filho

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Objectives:The advance of cryopreservation techniques turn possible the use of new strategies for LH supression during in vitro fertilization (IVF) cycles. Methods: The use of progesterone instead of gonadotropin-releasing hormone (GnRH) analogues seems to be a feasible option. Desogestrel is a progesterone broadly known and accepted in the context of contraception, with a good tolerability and low cost, in addition to a potent anti-ovulatory potency. Results: The present case is the first describing a succesfully controlled ovarian hyperstimulation (COH) for social oocyte cryopreservation using desogestrel 75mcg as a LH blocker in a healthy 35-year-old woman. Conclusions: the use of progesterone for LH supression seems to be a great option in the context of oocyte cryopreservation, since it is safe, less expensive and patient-friendly, avoiding the daily injections of GnRH analogues.


progesterone; desogestrel; in vitro fertilization; cryopreservation.


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