Human Reproduction Archives
https://humanreproductionarchives.com/article/doi/10.4322/hra.003519
Human Reproduction Archives
Original Article Infertility

Factors associated with the success of intracytoplasmic sperm injection for the treatment of conjugal infertility

Rodrigo Dias Nunes, Tássia Beatriz Freiberger Vieira, Jefferson Traebert

Downloads: 0
Views: 203

Abstract

Objectives: Obtaining and maintaining pregnancy after intracytoplasmic sperm injection (ICSI) may be affected by many technical factors. The goal of this study is to determine the rates of success from ICSI technique with established parameters and assess the associated factors to its success to treat infertility. Methods: A cross-sectional study involving 115 infertile couples submitted to ICSI was performed to test the association between technical aspects and success rates, from July 2013 to December 2014. Data collection was done through medical records. The bivariate associations were calculated by prevalence ratios and a Poisson regression was performed with significance level p < 0.05. Results: The aspiration of eight or more oocytes was 0.73 times (CI 95% 0.57-0.94) less associated (p = 0.014), but transferring two or more embryos was 1.75 times (CI 95% 1.54-1.99) more associated with the viable pregnancy (p < 0.001). The remaining characteristics of the ICSI procedures were not significantly associated with the expected outcome. Conclusions: The prevalence of the viable pregnancy after ICSI procedure was 40.9%. This index was positively influenced by the aspiration of less than eight oocytes and the transferring of two or more embryos.

Keywords

infertility; pregnancy rate; sperm injections, intracytoplasmic

References

1. Pasqualotto FF. Investigation and assisted reproduction in the treatment of male infertility. Rev Bras Ginecol Obstet. 2007;29(2):103- 12. http://dx.doi.org/10.1590/S0100-72032007000200008.

2. Rashidi B, Montazeri A, Ramezanzadeh F, Shariat M, Abedinia N, Ashrafi M. Health-related quality of life in infertile couples receiving IVF or ICSI treatment. BMC Health Serv Res. 2008;8(1):186. http://dx.doi.org/10.1186/1472-6963-8-186. PMid:18803838.

3. Marino JL, Moore VM, Rumbold AR, Davies MJ. Fertility treatments and the young women who use them: an Australian cohort study. Hum Reprod. 2011;26(2):473-9. http://dx.doi.org/10.1093/humrep/deq305. PMid:21071491.

4. Jin R, Bao J, Tang D, Liu F, Wang G, Zhao Y, et al. Outcomes of intracytoplasmic sperm injection using the zona pellucida-bound sperm or manually selected sperm. J Assist Reprod Genet. 2016;33(5):597-601. http://dx.doi.org/10.1007/s10815-016-0676-6. PMid:26941098.

5. Ashrafi M, Madani T, Movahedi M, Arabipoor A, Karimian L, Mirzaagha E, et al. Increasing the number of embryos transferred from two to three, does not increase pregnancy rates in good prognosis patients. Int J Fertil Steril. 2015;9(3):292-9. PMid:26644851.

6. Povlsen BB, Aw LD, Laursen RJ, Esteves SC, Humaidan P. Pregnancy and birth after intracytoplasmic sperm injection with normal testicular spermatozoa in a patient with azoospermia and tail stump epididymal sperm. Int Braz J Urol. 2015;41(6):1220-5. http://dx.doi.org/10.1590/S1677-5538.IBJU.2015.0296. PMid:26742983.

7. Ugajin T, Terada Y, Hasegawa H, Nabeshima H, Suzuki K, Yaegashi N. The shape of the sperm midpiece in intracytoplasmic morphologically selected sperm injection relates sperm centrosomal function. J Assist Reprod Genet. 2010;27(2-3):75-81. http://dx.doi.org/10.1007/s10815-009-9371-1. PMid:20012684.

8. Maiburg M, Alizadeh B, Kastrop P, Lock M, Lans S, Giltay J. Does the genetic and familial background of males undertaking ICSI affect the outcome? J Assist Reprod Genet. 2009;26(6):297-303. http://dx.doi.org/10.1007/s10815-009-9315-9. PMid:19548080.

9. Hajder M, Hajder E, Husic A. The effects of total motile sperm count on spontaneous pregnancy rate and pregnancy after IUI treatment in couples with male factor and unexplained infertility. Med Arh. 2016;70(1):39-43. http://dx.doi.org/10.5455/medarh.2016.70.39-43. PMid:26980930.

10. Jawed S, Rehman R, Ali MA, Abdullah UH, Gul H. Fertilization rate and its determinants in intracytoplasmic sperm injection. Pak J Med Sci. 2016;32(1):3-7. PMid:27022334.

11. Braga DP, Halpern G, Figueira RC, Setti AS, Iaconelli AJ Jr, Borges EJ Jr. Food intake and social habits in male patients and its relationship to intracytoplasmic sperm injection outcomes. Fertil Steril. 2012;98(1):53-9. http://dx.doi.org/10.1016/j.fertnstert.2011.10.011. PMid:22078783.

12. Ghuman NK, Mair E, Pearce K, Choudhary M. Does age of the sperm donor influence live birth outcome in assisted reproduction? Hum Reprod. 2016;31(3):582-90. http://dx.doi.org/10.1093/humrep/dev331. PMid:26762315.

13. Lampe A, Schüßler G. Psychosocial factors in reproductive medicine. Z Psychosom Med Psychother. 2015;61(4):309-26. http://dx.doi.org/10.13109/zptm.2015.61.4.309. PMid:26646911.

14. Lahav-Baratz S, Koifman M, Shiloh H, Ishai D, Wiener-Megnazi Z, Dirnfeld M. Analyzing factors affecting the success rate of frozen-thawed embryos. J Assist Reprod Genet. 2003;20(11):444-8. http://dx.doi.org/10.1023/B:JARG.0000006705.46147.a2. PMid:14714822.

15. Pandian Z, Marjoribanks J, Ozturk O, Serour G, Bhattacharya S. Number of embryos for transfer following in vitro fertilisation or intra-cytoplasmic sperm injection. Cochrane Database Syst Rev. 2013;(7):CD003416. http://dx.doi.org/10.1002/14651858. CD003416.pub4. PMid:23897513.

16. Pabuccu EG, Caglar GS, Tangal S, Haliloglu AH, Pabuccu R. Testicular versus ejaculated spermatozoa in ICSI cycles of normozoospermic men with high sperm DNA fragmentation and previous ART failures. Andrologia. 2017;49(2):e12609. http://dx.doi.org/10.1111/and.12609. PMid:27108915.

17. Drakopoulos P, Blockeel C, Stoop D, Camus M, de Vos M, Tournaye H, et al. Conventional ovarian stimulation and single embryo transfer for IVF/ICSI. How many oocytes do we need to maximize cumulative live birth rates after utilization of all fresh and frozen embryos? Hum Reprod. 2016;31(2):370-6. http://dx.doi.org/10.1093/humrep/dev316. PMid:26724797.

18. McAvey B, Zapantis A, Jindal SK, Lieman HJ, Polotsky AJ. How many eggs are needed to produce an assisted reproductive technology baby: is more always better? Fertil Steril. 2011;96(2):332-335. http://dx.doi.org/10.1016/j.fertnstert.2011.05.099. PMid:21718991.

19. Briggs R, Kovacs G, MacLachlan V, Motteram C, Baker HW. Can you ever collect too many oocytes? Hum Reprod. 2015;30(1):81-7. http://dx.doi.org/10.1093/humrep/deu272. PMid:25362088.

20. Liebaers I, Desmyttere S, Verpoest W, De Rycke M, Staessen C, Sermon K, et al. Report on a consecutive series of 581 children born after blastomere biopsy for preimplantation genetic diagnosis. Hum Reprod. 2010;25(1):275-82. http://dx.doi.org/10.1093/ humrep/dep298. PMid:19713301.

21. Kaur P, Swarankar ML, Maheshwari M, Acharya V. A comparative study between cleavage stage embryo transfer at day 3 and blastocyst stage transfer at day 5 in in-vitro fertilization/intra-cytoplasmic sperm injection on clinical pregnancy rates. J Hum Reprod Sci. 2014;7(3):194-7. http://dx.doi.org/10.4103/0974-1208.142481. PMid:25395745.

22. Santos MJ, Arroyo G, Busquet A, Calderón G, Cuadros J, Mendoza MVH, et al. ASEBIR interest Group in Embryology. A multicenter prospective study to assess the effect of early cleavage on embryo quality, implantation, and live-birth rate. Fertil Steril. 2014;101(4):981-7. http://dx.doi.org/10.1016/j.fertnstert.2013.12.043. PMid:24502893.

23. Cissen M, Bensdorp A, Cohlen BJ, Repping S, de Bruin JP, van Wely M. Assisted reproductive technologies for male subfertility. Cochrane Database Syst Rev. 2016;2:CD000360. PMid:26915339.

5dd828920e88257c1413f289 hra Articles
Links & Downloads

Hum Reprod Arch

Share this page
Page Sections