Human Reproduction Archives
Human Reproduction Archives
Research Article Gynecological Endocrinology

Uterine morphological changes induced by androgenic anabolic steroids

Eryck Holmes Alves da Silva, Igor Rafael Praxedes de Sales, Lucas Norberto de Oliveira, Expedito Silva do Nascimento Jr

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Objectives: The aim of this study was to evaluate morphological alterations in uterus induced by the irrational use of Anabolic Androgenic Steroids (AAS), particularly Nandrolone decanoate (ND). Methods: This paper presents a retrospective study of scientific articles available in full and free electronic access, using the platform PubMed in Portuguese and English, that reviews the effects of isolated ND use on the uterus and reproductive parameters in experimental animals. Results: AAS besides causing various systemic effects, in certain experimental animals alters uterine histological patterns. Histological analysis of the uterus of rats treated with ND showed deleterious effects, i.e., vacuolization and edema of the endometrial stroma. Conclusions: Thus, we conclude that use of ND shows high reproductive risks and can cause both damages and irreversible physiological changes.


nandrolone decanoate; reproduction; uterus; steroids.


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