Human Reproduction Archives
https://humanreproductionarchives.com/article/doi/10.4322/hra.000423
Human Reproduction Archives
REVIEW ARTICLE

SPERM DNA FRAGMENTATION: A NARRATIVE REVIEW

Mario Henrique Bitar Siqueira

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Abstract

Objectives: This study examines the impact of sperm DNA fragmentation on male fertility, pregnancy outcomes, the success rates of assisted reproductive technologies (ART), and the available treatments. Methods: This study is a narrative review focusing on infertility, “sperm DNA fragmentation” and “sperm count” using papers published in PUBMED, Scopus, and Google Scholar from 2019 to 2022 in Spanish, Portuguese, and English. Results: A total of 29 studies were selected, demonstrating that reactive oxygen species play a central role in sperm DNA damage, impairing fertilization. Sperm DNA fragmentation is further influenced by factors such as oxidative stress, leukospermia, advanced paternal age, and environmental pollutants. Conclusions: While ART can help overcome some of the challenges posed by DNA fragmentation, it remains a significant barrier to fertility.

Keywords

Infertility; Sperm Count; sperm DNA fragmentation

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Submitted date:
10/09/2023

Accepted date:
11/20/2024

677d157ca953956e190ac243 hra Articles
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