Human Reproduction Archives
https://humanreproductionarchives.com/article/doi/10.4322/hra.000418
Human Reproduction Archives
Review Article Assisted Reproduction

Meta-analysis comparing “freeze-all strategy” with traditional cycle of in vitro fertilization and fresh embryo transfer

Diego Mendes Do Carmo, Eduardo Camelo de Castro, Amanda Rincon Godinho, Antônio Márcio Teodoro Cordeiro Silva

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Abstract

Objective: To perform a meta-analysis comparing the outcomes of the freeze-all strategy with traditional cycles of in vitro fertilization and fresh embryo transfer. Methods: We used the Pubmed, EMBASE and Cochrane virtual databases, and used descriptors such as Assisted Reproductive Techniques, Fresh embryo transfer, Frozen-thawed embryo transfer, Freeze-all embryo transfer. Quality randomized controlled trials comparing transfer techniques were included. The variables of interest analyzed were the rates of pregnancy, clinical pregnancy, ongoing pregnancy and abortion, with each study containing at least one of these. Results: Five studies were selected. For rates of clinical pregnancy and ongoing pregnancy, there was greater success for the freeze-all strategy. There was no statistical difference for the rate of chemical pregnancy. The abortion rate had in the transfer of frozen a protective factor. Conclusions: Among the analyzed variables, it was indicated that the freeze-all strategy stands out. This leads us to a direction that the freezing techniques have already reached a level where we can, fearless, wait for a next cycle, that is more physiological and that the technique is better tolerated by the female organism.

Keywords

assisted reproductive techniques; embryo transfer; fertilization in vitro.

References

1. Evans J, Hannan NJ, Edgell TA, Vollenhoven BJ, Lutjen PJ, Osianlis T, et al. Fresh versus frozen embryo transfer: backing clinical decisions with scientific and clinical evidence. Hum Reprod Update. 2014;20(6):808-21. http://dx.doi.org/10.1093/humupd/dmu027. PMid:24916455.

2. Braga DP, Setti AS, Figueira RC, Azevedo MC, Iaconelli Junior A, Turco EGL, et al. Freeze-all, oocyte vitrification, or fresh embryo transfer? Lessons from an egg-sharing donation program. Fertil Steril. 2016;106(3):615-22. http://dx.doi.org/10.1016/j.fertnstert.2016.05.004. PMid:27262501.

3. Castro EC, Borges ALF, Rezende KN, Amaral WN. Antral follicle count in predicting appropriate dose of gonadotropin in in vitro fertilization cycles. Reprod Clim. 2014;29(3):136-42.

4. Castro AA, Guidugli F. Projeto de pesquisa de uma revisão sistemática. In: Castro AA, editor. Planejamento da pesquisa [Internet]. São Paulo: AAC; 2001 [cited 2017 Jul 10]. p. 1-37. Available from: http://www.usinadepesquisa.com/pdf/pesquisar/lv4_15_rsl.PDF

5. Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Hudson C, Thomas S. Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfers in high responders. Fertil Steril. 2011;96(2):516-8. PMid:21737071.

6. Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Hudson C, Thomas S. Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfer in normal responders. Fertil Steril. 2011;96(2):344-8. PMid:21737072.

7. Chen ZJ, Shi Y, Sun Y, Zhang B, Liang X, Cao Y, et al. Fresh versus frozen embryos for infertility in the polycystic ovary syndrome. N Engl J Med. 2016;375(6):523-33. http://dx.doi.org/10.1056/NEJMoa1513873. PMid:27509101.

8. Vuong LT, Dang VQ, Ho TM, Huynh BG, Ha DT, Pham TD, et al. Freeze-all versus fresh embryo transfer in IVF/ICSI, a randomised controlled trial. Fertil Steril. 2016;106(3):e376. http://dx.doi.org/10.1016/j.fertnstert.2016.08.006

9. Coates A, Kung A, Mounts E, Hesla J, Bankowski B, Barbieri E, et al. Optimal euploid embryo transfer strategy, fresh versus frozen, after preimplantation genetic screening with next generation sequencing: a randomized controlled trial. Fertil Steril. 2017;107(3):723-30. http://dx.doi.org/10.1016/j.fertnstert.2016.12.022. PMid:28139240.

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